1) It would seem that Johnson's bombardment of anti-aging devices would be akin to Michael Jackson's obsession with changing his looks.

2) Everyone is talking about too much inflammation (and anti-inflammatories like Rapamycin) but not about too-little inflammation (which of course can invite disease).

3) As you often say, exercise is a great "normalizing" component, it seems to balance our inflammatory levels. Many of Johnson's devices seem exercise stand-ins that may not have the same effect.

4) Aging is good in many ways...it turns a child into an adult for instance. Senescence has even been shown to be a protective against cancer. I suppose we are meant to age for a purpose. Living to a healthy 100 years is reasonable, maybe well beyond a kind of "Franken-aging" with some negative societal effects (like fighting evolution, not relinquishing control)

5) Testosterone seems headed in the estrogen replacement zone, reverses aging but possibly promotes cancer.

6) All told, many "good-news with bad-news" effects and diminishing returns.