Ok, not to go "Christian Science" on you, but some supporting information. Also, not to toot my own writing horn but 2 of my articles:

https://scottvern.medium.com/if-this-malady-dont-getcha-the-other-disease-will-5a01d3dc31d4

https://scottvern.medium.com/were-early-american-colonists-living-in-a-blue-zone-5f3e233cf462

I voraciously read Science Mag and Medium articles like yours. A "thread" that emerges, certainly, is that in these times big Medi-Pharma helps but is maybe 30% of the overall health picture (in history it was often better to avoid doctors/remedies). In peasant cultures, often there was better health due to simple veggie diets, hard work, family (with poor access to clean water) but that health picture has changed with Western diet. Obviously, Blue Zone (usually people w little Medical access) studies show that there's much more to longevity than doctors. If I were to draw a "health pyramid", I'd have diet/exercise/good environment at bottom, Vaccines/lay health workers/engineers who make clean air/water in the middle (basic health structures) and doctors/pills at the tip. There is a mystery about why heart attack/stroke have declined (and of course big Medi-Pharma will take all the credit) but my guess is this:

1) People quit eating so much trans fat

2) 1918 flu cohort died out/vaccines/antibiotics removed some of heart attack risk (due to addressing effects like we're seeing in long term Covid now)

3) People less likely to smoke/drink and/or more eat healthy/exercise now.

4) Nerd cohort (less robust mTOR response, longer living) survived more due to vaccines, started going to college and procreating, more robust mTOR group less advantaged, more inflammation in old age.

5) Certainly big Medi-Pharma has helped, ala Warfarin and Statins, blood pressure meds, surgical interventions but they may be overrated? Statins turn out to be anti-inflammatories too, available in natural products (Niacin/Red Rice Yeast), I sometimes wonder if "Blue Zone" people don't need all this stuff?

Three emerging threads? A) Funny/sad that from a few angles, vaccines best thing invented but currently feared? B) It's so much about inflammation and lazy people crave a pill but there's no sub for exercise? (corollary: it may not be what you eat but how much?) and C) Hard to escape that genetics is about 40% of it?

Sorry to hit you with all this but I don't always have time to write about it and you apparently do and are good at it, so go get em!