You're right, a very ambitious (and informative) article.

The "good news/bad news" of amyloid scaffolding reminds me of neutrophil nets...at best, they are the scaffolds of life (trapping invaders and allowing antibodies to destroy them), or at worst the scaffolds of death (trapping arteriosclerotic bacteria/lipids and/or providing rafts for metastatic cancer cells). What to do with these physiological frenemies? Some kind of bio-switch that selectively turns them on and off?